Bioactive Small Molecules
Cayman Chemical ANTIBODY SCH 900776 10mg
A functionally selective inhibitor of Chk1 (Kd = 2 nM; IC50 = 3 nM); interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce double-strand DNA breaks and cell death in tumor cells
Abcam PugNAc, he x osaminidase A and B inhibitor, 5MG
MW 353.33 Da, Purity >98%. Potent O-GlcNAcase, hexosaminidase A and B inhibitor (IC₅₀ values are 6, 25, 35 and 46 nM for β-hexosaminidase, HeX A/B, hOGA and OGA respectively). Decreases GLUT4 translocation and insulin-stimulated 2-deoxyglucose uptake in adipocytes. Shows antiapoptotic effects.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Hydroxy DImetrIdazole 5mg
A metabolite of dimetridazole, the nitroimidazole-based antibacterial and anticoccidial agent suspected to be carcinogenic and mutagenic to humans
Abcam WP1066, JAK/STAT3 inhibitor, 5MG
MW 356.2 Da, Purity >97%. JAK/STAT3 inhibitor (IC₅₀ = 2.3 μM). More potent analog of AG 490 (ab120950). Antitumor activity in vitro and in vivo. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Furosemide, Na+/2Cl-/K+ cotransporter inhibitor, 10G
MW 330.74 Da, Purity >99%. Inhibitor of the Na+/2Cl-/K+ cotransporter. Loop diuretic. Also acts as a non-competitive antagonist at GABAA receptors displaying approx. 100-fold greater selectivity for α6-containing receptors over α1-containing receptors.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical N-methyl Benzedronhydrochl 5mg
A cathinone whose physiological and toxicological properties are not known
TARGETMOL CHEMICALS INC FIIN-1 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8 6.9 5.4 120 32 and 120 nM for FGFR1 FGFR2 FGFR3 FGFR4 Flt1 Flt14 respectively.FIIN-1 inhibited FGFR1 FGFR2 FGFR3 FGFR4 with IC50 of 9.2 6.2 11.9 and 189 nM. FIIN-1 inhibited FGFR1 FGFR2 FGFR3 and FGFR4 with IC50s of 9.2 6.2 11.9 and 189 nM respectively. purity: 97%
Cayman Chemical ANTIBODY Eucalyptol 10mg
A bicyclic monoterpene; inhibits ionomycin- and PMA-induced TNF-α, IL-1β, IL-4, and IL-5 production by primary human lymphocytes at 10 μM; decreases LPS-induced mucus production by primary human nasal turbinate slices at 10 μM; decreases carrageenan-induced hind paw edema in rats and reduces the time spent licking the hind paw in a formalin-induced nociception test in mice at 400 mg/kg; inhibits A. aegypti mosquitoes from feeding on anesthetized gerbils when applied topically at 10% and from laying eggs in an ovipositional bioassay at 1% in standing water
Cayman Chemical ANTIBODY ENMD-2076 1mg
A multi-kinase inhibitor; inhibits FLT3, RET, and Aurora A kinase (IC50s = 1.86, 10.4, and 14 nM, respectively); inhibits additional kinases involved in angiogenesis (IC50s = 50s = via oral gavage); decreases tumor vascular permeability and perfusion and inhibits tumor growth in human TNBC and colorectal cancer mouse xenograft models of (100 mg/kg via oral gavage)
Medchemexpress LLC CCR7 antagonist 1 (30c) | 99.6% | 310.42 g·mol⁻1 | C13H22N6OS | 10 MG
CCR7 antagonist 1 is a small-molecule dual antagonist of the chemokine receptors CXCR2 and CCR7, intended for laboratory research. It displays measured IC50 values of 11.02 μM for CXCR2 and 0.43 μM for CCR7, is described with molecular formula C13H22N6OS and molecular weight 310.42 g·mol⁻1, and is provided in small research pack sizes at high reported purity.
- Dual CXCR2 and CCR7 antagonism with quantified IC50 values.
- Potent CCR7 inhibition (IC50 0.43 μM) useful for receptor biology studies.
- Characterized molecular formula and molecular weight for compound identification.
- High reported purity (~99.6%) for reliable experimental use.
- Available in small research pack sizes suitable for in vitro assays.
- Provided for research use only; not for human or clinical use.
Cayman Chemical GIlterItInIb 5mg
A FLT3 inhibitor (IC50 = 5 nM for the wild-type enzyme); inhibits various FLT3 mutants (IC50s = 1.4-12.2 nM); also inhibits Axl and c-Kit (IC50s = 41 and 102 nM, respectively); decreases the viability of blast cells isolated from patients with relapsed AML in a concentration-dependent manner
Medchemexpress LLC Gamma-glutamylserine | 5875-35-4 | 98.4% | C8H14N2O6 | 10MG
γ-Glutamylserine is a small-molecule amino acid derivative that functions as a calcium receptor activator. Provided as a white to off-white solid with formula C8H14N2O6 (MW 234.21), it is used in research on calcium receptor signaling and disease models such as Parkinson's disease, diabetes, and obesity.
- High purity (98.4%).
- White to off-white solid appearance.
- Soluble in DMSO at 100 mg/mL; may require sonication.
- Stable when stored sealed at -80°C (powder) for up to 2 years.
- Suitable for in vitro research on calcium receptor activity and metabolic disease models.
Cayman Chemical ANTIBODY PF-299804 5mg
An irreversible pan-ErbB receptor tyrosine kinase inhibitor (IC50s = 6, 45.7, and 73.7 nM for ErbB1, ErbB2, and ErbB4, respectively); demonstrates antitumor activity in various tumor xenograft models expressing either wild-type ErbB or mutant ErbB family members that show resistance to first generation ErbB kinase inhibitors
Cayman Chemical ANTIBODY CAY10608 10mg
A propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM); does not inhibit other NMDA subunits, AMPA receptors, or kainate receptors; has neuroprotective effects in vitro and in vivo
Medchemexpress LLC WEHI-9625 | 2595314-46-6 | 99.5% | 25 MG
WEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. It binds to VDAC2, promoting its ability to inhibit apoptosis driven by mouse BAK. It is completely inactive against both human BAK and the related apoptosis effector BAX. Intended for research use only.
- Tricyclic sulfone structure
- First-in-class inhibitor of apoptosis
- Binds to VDAC2
- Promotes VDAC2's ability to inhibit apoptosis driven by mouse BAK
- Inactive against human BAK and BAX